Dong Hun Kang, Sung Cheon Ko, Yu Been Heo, Hyun Jeong Lee, Han Min Woo Abstract Efficient and versatile DNA assembly frameworks have had an impact on promoting synthetic biology to build complex biological systems. To accelerate system development, laboratory automation (or biofoundry) provides an opportunity to construct organisms and DNA assemblies via computer-aided design.
Ping Han, Maybelle K. Go, Jeng Yeong Chow, Bo Xue, Yan Ping Lim, Michael A. Crone, Marko Storch, Paul S. Freemont & Wen Shan Yew Given the global over-reliance on commercial, kit-based RNA extraction in the molecular diagnoses of infectious diseases such as SARS-CoV-2, past challenges in the event of supply chain disruptions have hindered testing capacity in times of need. Apart from supply
DNA synthesis has become a major enabler of modern bioengineering, allowing scientists to simply order online in silico-designed DNA molecules. Rapidly decreasing DNA synthesis service prices and the concomitant increase of research and development scales bolstered by computer-aided DNA design tools and laboratory automation has driven up the demand for synthetic DNA.
A biofoundry provides automation and analytics infrastructure to support the engineering of biological systems. It allows scientists to perform synthetic biology and aligned experimentation on a high-throughput scale, massively increasing the solution space that can be examined for any given problem or question.
Binay Panda, Pawan K Dhar Abstract Biofoundry is a place where biomanufacturing meets automation. The highly modular structure of a biofoundry helps accelerate the design-build–test–learn workflow to deliver products fast and in a streamlined fashion. In this perspective, we describe our efforts to build Biofoundry India, where we see the facility add a substantial value in
Michael A. Crone, Miles Priestman, Marta Ciechonska, Kirsten Jensen, David J. Sharp, Arthi Anand, Paul Randell, Marko Storch & Paul S. Freemont A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics | Nature Communications