RoboMoClo: A Robotics-Assisted Modular Cloning Framework for Multiple Gene Assembly in Biofoundry

Dong Hun Kang, Sung Cheon Ko, Yu Been Heo, Hyun Jeong Lee, Han Min Woo Abstract Efficient and versatile DNA assembly frameworks have had an impact on promoting synthetic biology to build complex biological systems. To accelerate system development, laboratory automation (or biofoundry) provides an opportunity to construct organisms and DNA assemblies via computer-aided design.

A high-throughput pipeline for scalable kit-free RNA extraction

Ping Han, Maybelle K. Go, Jeng Yeong Chow, Bo Xue, Yan Ping Lim, Michael A. Crone, Marko Storch, Paul S. Freemont & Wen Shan Yew Given the global over-reliance on commercial, kit-based RNA extraction in the molecular diagnoses of infectious diseases such as SARS-CoV-2, past challenges in the event of supply chain disruptions have hindered testing capacity in times of need. Apart from supply

Building a global alliance of biofoundries

Nathan Hillson, Mark Caddick, […]Paul S. Freemont Nature Communications volume 10, Article number: 2040 (2019) Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.